Discovery of dihydrooxazolo[2,3-a]isoquinoliniums as highly specific inhibitors of hCE2-Reference-Cited by-同舟云学术

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Discovery of dihydrooxazolo[2,3-a]isoquinoliniums as highly specific inhibitors of hCE2

Published:2019 Issue:61 Volume:9 Page:35904-35912
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Ding Lixia¹²³⁴⁵,Wang Lu⁶⁵⁷,Zou Kun¹²³⁴⁵,Li Bo¹²³⁴⁵^ORCID,Song Yunqing⁶⁵⁷,Zhang Qihua¹²³⁴⁵,Zhao Yitian⁶⁵⁷,Xu Zhijian¹²³⁴⁵^ORCID,Ge Guangbo⁶⁵⁷,Zhao Bo⁸⁹¹⁰⁷,Zhu Weiliang¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Receptor Research

2. Drug Discovery and Design Center

3. Shanghai Institute of Materia Medica

4. Chinese Academy of Sciences

5. Shanghai 201203

6. Shanghai University of Traditional Chinese Medicine

7. China

8. College of Chemistry and Materials Science

9. Nanjing Normal University

10. Nanjing 210097

Abstract

Novel oxazoliniums are highly specific inhibitors of hCE2 over hCE1 and have good cell-membrane permeability for inhibiting intracellular hCE2.

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Natural Science Foundation of Shanghai

Program of Shanghai Academic Research Leader

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA07457K

Reference43 articles.

1. Carboxylesterase Inhibitors: An Update

2. Recent progress in the discovery of natural inhibitors against human carboxylesterases

3. Human carboxylesterases: a comprehensive review

4. HYDROLYSIS OF IRINOTECAN AND ITS OXIDATIVE METABOLITES, 7-ETHYL-10-[4-N-(5-AMINOPENTANOIC ACID)-1-PIPERIDINO] CARBONYLOXYCAMPTOTHECIN AND 7-ETHYL-10-[4-(1-PIPERIDINO)-1-AMINO]-CARBONYLOXYCAMPTOTHECIN, BY HUMAN CARBOXYLESTERASES CES1A1, CES2, AND A NEWLY EXPRESSED CARBOXYLESTERASE ISOENZYME, CES3

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