In proteins, the structural responses of a position to mutation rely on the Goldilocks principle: not too many links, not too few-Reference-Cited by-同舟云学术

In proteins, the structural responses of a position to mutation rely on the Goldilocks principle: not too many links, not too few

Published:2018 Issue:39 Volume:20 Page:25399-25410
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Dorantes-Gilardi Rodrigo¹²³⁴⁵,Bourgeat Laëtitia⁶⁷⁸⁹⁵,Pacini Lorenza¹⁰¹¹¹²⁵⁶,Vuillon Laurent¹²³⁴⁵,Lesieur Claire¹⁰¹¹¹²⁵⁶^ORCID

Affiliation:

1. LAMA

2. Univ. Savoie Mont Blanc

3. CNRS, LAMA

4. 73376 Le Bourget du Lac

5. France

6. AMPERE

7. CNRS

8. Univ. Lyon

9. 69622, Lyon

10. Institut Rhônalpin des systèmes complexes

11. IXXI-ENS-Lyon

12. Lyon

Abstract

A disease has distinct genetic and molecular hallmarks such as sequence variants that are likely to produce the alternative protein structures accountable for individual responses to drugs and disease development.

Funder

Centre National de la Recherche Scientifique

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CP/C8CP04530E

Reference65 articles.

1. Unraveling cell-to-cell signaling networks with chemical biology

2. Conformational diversity and the emergence of sequence signatures during evolution

3. The Evolution and Structure Prediction of Coiled Coils across All Genomes

4. Protein homeostasis: live long, won't prosper

5. Architecture of the polyketide synthase module: surprises from electron cryo-microscopy

Cited by 19 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Network-Based Molecular Descriptors for Protein Dynamics and Allosteric Regulation;Synthesis Lectures on Mathematics & Statistics;2024-09-03

2. Reviewing the Structure–Function Paradigm in Polyglutamine Disorders: A Synergistic Perspective on Theoretical and Experimental Approaches;International Journal of Molecular Sciences;2024-06-20

3. Connected Component Analysis of Dynamical Perturbation Contact Networks;The Journal of Physical Chemistry B;2023-08-29

4. GCAT: A network model of mutational influences between amino acid positions in PSD95pdz3;Frontiers in Molecular Biosciences;2022-10-31

5. A protocol to measure slow protein dynamics of the cholera toxin B pentamers using broadband dielectric spectroscopy;STAR Protocols;2022-09