Cyclisation strategies for stabilising peptides with irregular conformations-Reference-Cited by-同舟云学术

Cyclisation strategies for stabilising peptides with irregular conformations

Published:2021 Issue:6 Volume:12 Page:887-901
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Vu Quynh Ngoc¹²³,Young Reginald¹²³,Sudhakar Haritha Krishna¹²³,Gao Tianyi¹²³,Huang Tiancheng¹²³^ORCID,Tan Yaw Sing⁴⁵⁶⁷^ORCID,Lau Yu Heng¹²³^ORCID

Affiliation:

1. School of Chemistry, Eastern Ave

2. The University of Sydney

3. Australia

4. Bioinformatics Institute

5. Agency for Science, Technology and Research (A*STAR)

6. Singapore 138671

7. Singapore

Abstract

There are remarkably few examples of designing cyclic constraints for peptides which adopt an irregular conformation in their bioactive state. We discuss the design strategies, opportunities and challenges for this underexplored class of inhibitors.

Funder

Australian Research Council

Westpac Scholars Trust

National Health and Medical Research Council

Agency for Science, Technology and Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00098E

Reference92 articles.

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