Oxazoline scaffold in synthesis of benzosiloxaboroles and related ring-expanded heterocycles: diverse reactivity, structural peculiarities and antimicrobial activity

Author:

Krajewska Joanna1ORCID,Nowicki Krzysztof2ORCID,Durka Krzysztof2ORCID,Marek-Urban Paulina H.2ORCID,Wińska Patrycja2ORCID,Stępniewski Tomasz3ORCID,Woźniak Krzysztof4ORCID,Laudy Agnieszka E.1ORCID,Luliński Sergiusz2ORCID

Affiliation:

1. Department of Pharmaceutical Microbiology, Medical University of Warsaw, Banacha 1 b, 02-097, Warsaw, Poland

2. Warsaw University of Technology, Faculty of Chemistry, Noakowskiego 3, 00-664 Warsaw, Poland

3. GPCR Drug Discovery Lab, Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM) – Department of Experimental and Health Sciences of Pompeu Fabra University (UPF), Carrer del Dr Aiguader, 88, 08003 Barcelona, Spain

4. University of Warsaw, Faculty of Chemistry, Pasteura 1, 02-093 Warsaw, Poland

Abstract

Transformations of oxazoline–benzosiloxaborole conjugates gave rise to novel boracyclic systems as well as functionalized derivatives featuring antibacterial activity.

Funder

Narodowe Centrum Nauki

European Social Fund

Politechnika Warszawska

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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