Small DNA circles as bacterial topoisomerase I inhibitors-Reference-Cited by-同舟云学术

Small DNA circles as bacterial topoisomerase I inhibitors

Published:2019 Issue:32 Volume:9 Page:18415-18419
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Li Dawei¹²³⁴⁵^ORCID,Wang Qiang¹²³⁴,Zhou Bing¹²³⁴,Zhuge Qiang¹²³⁴⁵,Lv Bei⁶⁷⁸³⁴^ORCID

Affiliation:

1. College of Biology and the Environment

2. Nanjing Forestry University

3. Nanjing

4. China

5. The Southern Modern Forestry Collaborative Innovation Center

6. Jiangsu Key Laboratory for Biofunctional Molecules

7. College of Life Science and Chemistry

8. Jiangsu Second Normal University

Abstract

It is demonstrated that small DNA circles showed high inhibitory effect on the activity of bacterial topoisomerase I and the single-stranded regions associated with bending deformation are believed to be the crucial factor for trapping the enzymes.

Funder

Natural Science Foundation of Jiangsu Province

Nanjing Forestry University

Jiangsu Second Normal University

Natural Science Research of Jiangsu Higher Education Institutions of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA02398D

Reference35 articles.

1. Supercoiling in DNA and chromatin

2. DNA Topoisomerases: Structure, Function, and Mechanism

3. DNA TOPOISOMERASES

4. The benefit of DNA supercoiling during replication

5. A. D.Bates and A.Maxwell , DNA Topology , Oxford University Press , Oxford, New York , 2nd edn, 2005

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