Hydroxytyrosol ameliorates stress-induced liver injury through activating autophagy <i>via</i> HDAC1/2 inhibition-Reference-Cited by-同舟云学术

Hydroxytyrosol ameliorates stress-induced liver injury through activating autophagy via HDAC1/2 inhibition

Published:2024 Issue:9 Volume:15 Page:5103-5117
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Fan Li¹²,Zhao Lijuan¹²,Zhu Yangbo³,Li Lin¹²,Yang Xueping⁴,Ma Ping⁵,Liu Jian¹²,Zhao Qingwei¹²,Li Xiaobo⁵²^ORCID

Affiliation:

1. Department of Clinical Pharmacy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China

2. Zhejiang Provincial Key Laboratory of Traditional Chinese Medicine for Clinical Evaluation and Translational Research, Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China

3. Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China

4. Department of Integrated Traditional Chinese and Western Medicine, Institute of Integrative Medicine, Xiangya Hospital, Central South University, Changsha 410008, China

5. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China

Abstract

The first evidence that HT induces autophagy in the hepatocytes by targeting HDAC1/2 for maintaining mitochondrial dysfunction, thus preventing inflammation and oxidative stress for exerting an anti-SLI effect.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/FO/D4FO01027B

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