Efficient delivery of carotenoids to adipocytes with albumin

Author:

Mazurkiewicz Joanna12ORCID,Stanek Ewa13ORCID,Kolodziejczyk Aleksandra12ORCID,Karpiel Marta12ORCID,Czamara Krzysztof3ORCID,Ferreira Tiago H.4,Maximiano Pedro4ORCID,Simões Pedro N.4ORCID,Reva Igor4ORCID,Kalinowska-Tłuścik Justyna2ORCID,Kaczor Agnieszka2ORCID

Affiliation:

1. Doctoral School of Exact and Natural Sciences, Jagiellonian University, 11 Lojasiewicza Str., 30-348 Krakow, Poland

2. Faculty of Chemistry, Jagiellonian University, 2 Gronostajowa Str., 30-387 Krakow, Poland

3. Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, 14 Bobrzynskiego Str., 30-348 Krakow, Poland

4. CERES, Department of Chemical Engineering, University of Coimbra, 3030-790 Coimbra, Portugal

Abstract

A hydrophobic periphery area of albumin loosely bounds the self-aggregated astaxanthin in water and enables its easy detachment in hydrophobic environment. This explains the effectiveness of albumins as nanocarriers of carotenoids to adipocytes.

Funder

Narodowe Centrum Nauki

Fundação para a Ciência e a Tecnologia

Uniwersytet Jagielloński w Krakowie

Ministerstwo Edukacji i Nauki

Publisher

Royal Society of Chemistry (RSC)

Reference67 articles.

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1. Imaging of perivascular adipose tissue in cardiometabolic diseases by Raman spectroscopy: Towards single-cell analysis;Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids;2024-06

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