Bisphosphonate–polyaspartamide conjugates as bone targeted drug delivery systems

Author:

Paolino D.12345,Licciardi M.678910,Celia C.1112131014,Giammona G.678910,Fresta M.12345,Cavallaro G.678910

Affiliation:

1. Department of Health Sciences

2. #IRC FSH-Interregional Research Center for Food Safety &, Health

3. University of Catanzaro “Magna Graecia”

4. Campus Universitario “S. Venuta”

5. I-88100 Catanzaro

6. Department of Biological, Chemical and Pharmaceutical Sciences and Technologies

7. (STEBICEF), Sezione di Chimica e Tecnologie Farmaceutiche

8. Universita degli Studi di Palermo

9. 90123 Palermo

10. Italy

11. Department of Pharmacy

12. University of Chieti – Pescara “G. d'Annunzio”

13. Chieti 66013

14. Department of Nanomedicine

Abstract

Poly-hydroxy-aspartamide was used as a backbone to synthesize bisphosphonate derivatives thus achieving macromolecular carriers to be potentially used as targeting agents for bone drug delivery.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Reference27 articles.

1. H. Fleisch , A.Reszka, G. A.Rodan and M.Rogers, Principles of Bone Biology, ed. J. P. Bilezikian, L. G. Raisz and G. A. Rodan, Academic Press, San Diego, 2nd edn, 2002, ch. 10, pp. 1361–1385

2. M. D. Fancis and I.Fogelman, Bone Scanning in Clinical Pactice, ed. I. Fogelman, Springer-Verlag, New York, 1987, ch. 4, pp. 7–17

3. Samarium 153Sm Lexidronam

4. Synthesis and Evaluation of Water-Soluble Polymeric Bone-Targeted Drug Delivery Systems

5. Synthesis and characterization of surface‐modified PBLG nanoparticles for bone targeting: In vitro and in vivo evaluations

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