Design, synthesis, anticancer activity, molecular docking and ADME studies of novel methylsulfonyl indole-benzimidazoles in comparison with ethylsulfonyl counterparts-Reference-Cited by-同舟云学术

Design, synthesis, anticancer activity, molecular docking and ADME studies of novel methylsulfonyl indole-benzimidazoles in comparison with ethylsulfonyl counterparts

Published:2021 Issue:20 Volume:45 Page:9010-9019
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Karadayi Fikriye Zengin¹²³⁴⁵,Yaman Murat⁶⁷⁴⁵,Kisla Mehmet Murat¹²³⁴⁵^ORCID,Konu Ozlen⁶⁷⁴⁵⁸,Ates-Alagoz Zeynep¹²³⁴⁵^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry

2. Faculty of Pharmacy

3. Ankara University

4. Ankara

5. Turkey

6. Interdisciplinary Program in Neuroscience

7. Bilkent University

8. Department of Molecular Biology and Genetics

Abstract

Specific sidechain modifications on the indole-benzimidazole scaffold play fundamental roles for determining molecule's affinity against ERα and its anti-cancer activity.

Funder

Türkiye Bilimsel ve Teknolojik Araştirma Kurumu

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NJ/D1NJ01019K

Reference43 articles.

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3. Estrogen receptors alpha (ERα) and beta (ERβ): Subtype-selective ligands and clinical potential