In-flow photooxygenation of aminothienopyridinones generates iminopyridinedione PTP4A3 phosphatase inhibitors
Author:
Affiliation:
1. Department of Chemistry
2. University of Pittsburgh
3. Pittsburgh
4. USA
5. Department of Pharmacology
6. University of Virginia
7. Charlottesville
Abstract
A continuous flow photooxygenation of 7-aminothieno[3,2-c]pyridin-4(5H)-ones produces potent in vitro inhibitors of the cancer-associated protein tyrosine phosphatase PTP4A3.
Funder
U.S. Department of Defense
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB00025A
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