Mechanistic studies and radiofluorination of structurally diverse pharmaceuticals with spirocyclic iodonium(iii) ylides-Reference-Cited by-同舟云学术

Mechanistic studies and radiofluorination of structurally diverse pharmaceuticals with spirocyclic iodonium(iii) ylides

Published:2016 Issue:7 Volume:7 Page:4407-4417
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Rotstein Benjamin H.¹²³⁴⁵^ORCID,Wang Lu¹²³⁴,Liu Richard Y.⁶⁷⁸⁴,Patteson Jon¹²³⁴,Kwan Eugene E.⁶⁷⁸⁴,Vasdev Neil¹²³⁴⁵,Liang Steven H.¹²³⁴⁵

Affiliation:

1. Division of Nuclear Medicine and Molecular Imaging & Gordon Center for Medical Imaging

2. Massachusetts General Hospital

3. Boston

4. USA

5. Department of Radiology

6. Department of Chemistry and Chemical Biology

7. Harvard University

8. Cambridge

Abstract

Theoretical studies provide insight into radiofluorination of non-activated electron-rich and sterically hindered ¹⁸F-arenes using a new class of adamantyl-based spirocyclic iodonium(iii) ylide precursors.

Funder

National Institute on Drug Abuse

Massachusetts General Hospital

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SC/C6SC00197A

Reference54 articles.

1. Synthesis of11C,18F,15O, and13N Radiolabels for Positron Emission Tomography

2. Molecular Imaging with PET

3. Late-stage [18F]fluorination: new solutions to old problems

4. Modern Carbon–Fluorine Bond Forming Reactions for Aryl Fluoride Synthesis

5. Metal-Free Oxidative Fluorination of Phenols with [18F]Fluoride

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