Regioselective heterofunctionalization of alpha-aryl amides with heteroatom nucleophiles <i>via</i> electrophilic activation-Reference-Cited by-同舟云学术

Regioselective heterofunctionalization of alpha-aryl amides with heteroatom nucleophiles via electrophilic activation

Published:2023 Issue:21 Volume:10 Page:5512-5518
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Han Shuai¹,Guo Yu¹^ORCID,Zhang Wei¹,Chen Jinjin¹,Wang Zhen¹²^ORCID,Zeng Yao-Fu¹^ORCID

Affiliation:

1. School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China

2. MOE Key Lab of Rare Pediatric Diseases, University of South China, Hengyang, Hunan, 421001, China

Abstract

A general and efficient strategy for the α-heterofunctionalization of aryloxy-activated amides with various nucleophiles, including amines, alcohols, phenols, carboxylic acids, and thiols, has been developed.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hunan Province

Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D3QO01174G

Reference50 articles.

1. Rethinking amide bond synthesis

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5. Amide Bond Activation of Biological Molecules

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