Viral peptide conjugates for metal-warhead delivery to chromatin-Reference-Cited by-同舟云学术

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Viral peptide conjugates for metal-warhead delivery to chromatin

Published:2024 Issue:13 Volume:14 Page:8718-8725
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Batchelor Lucinda K.¹,De Falco Louis²,Dyson Paul J.¹^ORCID,Davey Curtis A.²^ORCID

Affiliation:

1. Institut des Sciences et Ingénierie Chimiques, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland

2. School of Biological Sciences & NTU Institute of Structural Biology, Nanyang Technological University (NTU), 637551, Singapore

Abstract

Chromatin-targeting viral peptide–gold(i) conjugates display cancer cell selectivity and localize to the nucleosome acidic patch, forming histone site-specific protein adducts.

Funder

Ministry of Education – Singapore

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA01617C

Reference37 articles.

1. Organometallic–Peptide Bioconjugates: Synthetic Strategies and Medicinal Applications

2. Peptide-mediated vectorization of metal complexes: conjugation strategies and biomedical applications

3. Viral Genome Tethering to Host Cell Chromatin: Cause and Consequences

4. Fighting Cancer with Transition Metal Complexes: From Naked DNA to Protein and Chromatin Targeting Strategies

5. Specific DNA structural attributes modulate platinum anticancer drug site selection and cross-link generation

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