Synthesis of broad-specificity activity-based probes for exo-β-mannosidases-Reference-Cited by-同舟云学术

Synthesis of broad-specificity activity-based probes for exo-β-mannosidases

Published:2022 Issue:4 Volume:20 Page:877-886
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

McGregor Nicholas G. S.¹^ORCID,Kuo Chi-Lin²,Beenakker Thomas J. M.²^ORCID,Wong Chun-Sing²,Offen Wendy A.¹^ORCID,Armstrong Zachary¹^ORCID,Florea Bogdan I.²^ORCID,Codée Jeroen D. C.²^ORCID,Overkleeft Herman S.²^ORCID,Aerts Johannes M. F. G.³,Davies Gideon J.¹^ORCID

Affiliation:

1. York Structural Biology Laboratory, Department of Chemistry, The University of York, York YO10 5DD, UK

2. Department of Bio-Organic Chemistry, Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands

3. Department of Medical Biochemistry, Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands

Abstract

New cyclophellitol-derived probes covalently label β-mannosidases, enabling the detection of diverse mannosidases via activity-based protein profiling.

Funder

Royal Society

Biotechnology and Biological Sciences Research Council

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

H2020 European Research Council

Diamond Light Source

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D1OB02287C