Size-related variability of oxygen consumption rates in individual human hepatic cells

Author:

Botte Ermes12ORCID,Cui Yuan34ORCID,Magliaro Chiara12,Tenje Maria4ORCID,Koren Klaus5,Rinaldo Andrea67,Stocker Roman8ORCID,Behrendt Lars3,Ahluwalia Arti12

Affiliation:

1. Research Centre “E. Piaggio”, University of Pisa, Pisa, Italy

2. Department of Information Engineering, University of Pisa, Pisa, Italy

3. Department of Organismal Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden

4. Department of Materials Science and Engineering, Science for Life Laboratory, Uppsala University, Uppsala, Sweden

5. Aarhus University Centre for Water Technology, Department of Biology, Aahrus University, 8000 Aarhus, Denmark

6. Laboratory of Ecohydrology ECHO/IIE/ENAC, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

7. Department of Civil, Environmental and Architectural Engineering, University of Padova, Padova, Italy

8. Institute for Environmental Engineering, Department of Civil, Environmental and Geomatic Engineering, ETH Zurich, Zurich, Switzerland

Abstract

Human hepatocytes confined in microwells cooperate in oxygen sharing and their size-metabolism covariance is lognormal.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Vetenskapsrådet

Novo Nordisk Fonden

European Commission

Carl Tryggers Stiftelse för Vetenskaplig Forskning

Publisher

Royal Society of Chemistry (RSC)

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