Primary amine C–N bond cleavage for the synthesis of multi-substituted pyridine and pyrrole derivatives

Author:

Zhang Ruiqin12,Ding Yuxin12,Ma Renchao1,Xiao Xuqiong3ORCID,Chen Rener1,Wang Lei1ORCID,Ma Yongmin12ORCID

Affiliation:

1. Institute of Advanced Studies and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang, 318000, P R China

2. School of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, 310053, P R China

3. Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, No. 2318 Yuhangtang Rd., Hangzhou, 311121, P R China

Abstract

Synthesis of multi-substituted pyridines and pyrroles was established and involved C-N bond cleavage and new C–N and C–C bond formation. The C–N bond adjacent to the primary carbon of 1,2-diamino-2-methylpropane was selectively cleaved.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

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