Novel synthesis of fused spiro piperidone-cyclopropanes from cyclopropyl amides and electron-deficient alkenes-Reference-Cited by-同舟云学术

Novel synthesis of fused spiro piperidone-cyclopropanes from cyclopropyl amides and electron-deficient alkenes

Published:2021 Issue:14 Volume:19 Page:3191-3198
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Han Xiao-Dan¹²³⁴^ORCID,Peng Gao-Liang⁵³⁴,Wang Hui-Bin¹²³⁴,Wu Lei¹²³⁴,Fu Jian-ping¹²³⁴,Tang Zhong-Sheng¹²³⁴,Hu Ju-Wu¹²³⁴^ORCID,Xiong Wei¹²³⁴

Affiliation:

1. Department of Applied Chemistry

2. Jiang Xi Academic of Sciences

3. Nanchang

4. China

5. Jiangxi university of Applied Science

Abstract

A novel tactic for the atom economical synthesis of bridged O,O-ketal fused spiro pyridone-cyclopropane derivatives 3 with excellent yields and good diastereoselectivity derived from 1-acylcyclopropanecarboxamides 1 and acrolein has been developed.

Funder

National Natural Science Foundation of China

Jiangxi Provincial Department of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB00214G

Reference45 articles.

1. Zur kenntnis der bitterstoffe aus cneoraceen, II

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3. Anti-inflammatory, antibacterial and molecular docking studies of novel spiro-piperidine quinazolinone derivatives

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5. Synthesis and biological characterization of spiro[2H-(1,3)-benzoxazine-2,4′-piperidine] based histone deacetylase inhibitors

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