Synthesis of 3-substituted quinolin-2(1H)-onesviathe cyclization ofo-alkynylisocyanobenzenes-Reference-Cited by-同舟云学术

Synthesis of 3-substituted quinolin-2(1H)-onesviathe cyclization ofo-alkynylisocyanobenzenes

Published:2018 Issue:38 Volume:16 Page:7050-7054
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Charoenpol Ailada¹²³⁴⁵,Meesin Jatuporn¹²³⁴⁵,Khaikate Onnicha¹²³⁴⁵,Reutrakul Vichai¹²³⁴⁵,Pohmakotr Manat¹²³⁴⁵^ORCID,Leowanawat Pawaret¹²³⁴⁵,Soorukram Darunee¹²³⁴⁵^ORCID,Kuhakarn Chutima¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC)

2. Faculty of Science

3. Mahidol University

4. Bangkok 10400

5. Thailand

Abstract

An efficient synthesis of 3-substituted quinolin-2(1H)-ones through sequential nucleophilic addition of water/6-endocyclization ofo-alkynylisocyanobenzenes is described.

Funder

Thailand Research Fund

Mahidol University

Office of the Higher Education Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB01882K

Reference95 articles.

1. 3-Phenyl-4-hydroxyquinolin-2(1H)-ones: potent and selective antagonists at the strychnine-insensitive glycine site on the N-methyl-D-aspartate receptor complex