Development of polycationic micelles as an efficient delivery system of antibiotics for overcoming the biological barriers to reverse multidrug resistance in Escherichia coli

Author:

Guo Rong12345,Li Keke12345,Qin Jing61789,Niu Shengli1011121314,Hong Wei12345ORCID

Affiliation:

1. School of Pharmacy

2. the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China

3. Binzhou Medical University

4. Yantai

5. P. R. China

6. Department of Pharmaceutics

7. Institute of Integrative Medicine

8. Fudan University

9. Key Laboratory of Smart Drug Delivery

10. Key laboratory of Zoonosis of Liaoning Province

11. College of Animal Science and Veterinary Medicine

12. Shenyang Agricultural University

13. Shenyang

14. P.R. China

Abstract

Schematic illustration of polycationic micelles targeting drug-resistant E. coli (A), biofilms (B), infected macrophages (C), and bacterial infection tissues (D).

Funder

Taishan Scholar Project of Shandong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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