Growth vector elaboration of fragments: regioselective functionalization of 5-hydroxy-6-azaindazole and 3-hydroxy-2,6-naphthyridine-Reference-Cited by-同舟云学术

Growth vector elaboration of fragments: regioselective functionalization of 5-hydroxy-6-azaindazole and 3-hydroxy-2,6-naphthyridine

Published:2022 Issue:37 Volume:20 Page:7483-7490
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Eliandro da Silva Júnior Paulo¹,de Melo Shaiani Maria Gil¹,de Paula Murilo Helder¹,Vessecchi Ricardo²,Opatz Till³^ORCID,Day James E. H.⁴,Ganesan A.⁵^ORCID,da Silva Emery Flavio¹⁶^ORCID

Affiliation:

1. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Departmento de Ciências Farmacêuticas, Universidade de São Paulo, Ribeirão Preto 14040-903, Brazil

2. Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, SP, 14040-901, Brazil

3. Department of Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10-14, Mainz 55128, Germany

4. Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, UK

5. School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK

6. Center for the Research and Advancement in Fragments and molecular Targets (CRAFT), Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, RIbeirão Preto, São Paulo, Brasil

Abstract

The expansion of the fragment chemical space by accessing growth vectors of two “heteroaromatic rings of the future” with regioselective functionalization is reported.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Astex Pharmaceuticals

Fundação de Amparo à Pesquisa do Estado de São Paulo

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00968D

Reference29 articles.

1. An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles

2. Heterocycles in drugs and drug discovery

3. Heteroaromatic Rings of the Future

4. Synthesis of two ‘heteroaromatic rings of the future’ for applications in medicinal chemistry

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