Conversion mechanism of enoyl thioesters into acyl thioesters catalyzed by 2-enoyl-thioester reductases from Candida Tropicalis-Reference-Cited by-同舟云学术

Conversion mechanism of enoyl thioesters into acyl thioesters catalyzed by 2-enoyl-thioester reductases from Candida Tropicalis

Published:2019 Issue:19 Volume:21 Page:10105-10113
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Ling Baoping¹²³⁴⁵^ORCID,Li Hong¹²³,Yan Lijuan¹²³,Liu Rutao¹²³^ORCID,Liu Yongjun¹²³^ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering & School of Environmental Science and Engineering, Shandong University

2. Jinan

3. China

4. School of Chemistry and Chemical Engineering, Qufu Normal University

5. Qufu

Abstract

Enoyl thioester reductase from Candida tropicalis (Etr1p) catalyzes the NADPH-dependent conversion of enoyl thioesters into acyl thioesters, which are essential in fatty acid and second metabolite biosynthesis.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CP/C9CP00987F

Reference54 articles.

1. Fatty acid synthesis and elongation in yeast

2. Diversity in enoyl-acyl carrier protein reductases

3. Mitochondrial fatty acid synthesis and maintenance of respiratory competent mitochondria in yeast

4. Structural Enzymological Studies of 2-Enoyl Thioester Reductase of the Human Mitochondrial FAS II Pathway: New Insights into Its Substrate Recognition Properties

5. Structure–function Analysis of Enoyl Thioester Reductase Involved in Mitochondrial Maintenance

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