Combined pressure and cosolvent effects on enzyme activity – a high-pressure stopped-flow kinetic study on α-chymotrypsin-Reference-Cited by-同舟云学术

Combined pressure and cosolvent effects on enzyme activity – a high-pressure stopped-flow kinetic study on α-chymotrypsin

Published:2015 Issue:35 Volume:17 Page:23273-23278
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Luong Trung Quan¹²³⁴,Winter Roland¹²³⁴

Affiliation:

1. Department of Chemistry and Chemical Biology

2. TU Dortmund University

3. D-44221 Dortmund

4. Germany

Abstract

Pressure enhances the hydrolysis of peptides catalysed by α-CT, which is efficiently and differently modulated by chaotropic and kosmotropic cosolvents.

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2015/CP/C5CP03529E

Reference47 articles.

1. Industrial enzyme applications

2. Engineered enzymes for chemical production

3. Influence of reaction conditions on the enantioselectivity of biocatalyzed C–C bond formations under high pressure conditions

4. Influence of Osmolytes and Denaturants on the Structure and Enzyme Activity of α-Chymotrypsin

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