Synthesis and evaluation of novel 12-aryl berberine analogues with hypoxia-inducible factor-1 inhibitory activity-Reference-Cited by-同舟云学术

Synthesis and evaluation of novel 12-aryl berberine analogues with hypoxia-inducible factor-1 inhibitory activity

Published:2017 Issue:43 Volume:7 Page:26921-26929
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zhou Xiaobo¹²³⁴⁵^ORCID,Chen Ming¹²³⁴⁵^ORCID,Zheng Zhiyuan¹²³⁴⁵^ORCID,Zhu Guo-Yuan¹²³⁴⁵^ORCID,Jiang Zhi-Hong¹²³⁴⁵^ORCID,Bai Li-Ping¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Quality Research in Chinese Medicine

2. Macau Institute for Applied Research in Medicine and Health

3. Macau University of Science and Technology

4. Taipa

5. China

Abstract

Seven novel 12-phenyl berberines (3a–3f, 3k) showed more potent inhibitory effect on hypoxia-induced HIF-1 transcriptional activity than the parent berberine.

Funder

FDCT

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA02238G

Reference48 articles.

1. Hypoxia — a key regulatory factor in tumour growth

2. Hypoxia and cancer

3. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

4. Purification and Characterization of Hypoxia-inducible Factor 1

5. HIF-1 as a target for drug development

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