Asymmetric hydrogenation of all-carbon tetrasubstituted α-acylpyrazole-β-alkyl cycloalkenes-Reference-Cited by-同舟云学术

Asymmetric hydrogenation of all-carbon tetrasubstituted α-acylpyrazole-β-alkyl cycloalkenes

Published:2023 Issue:20 Volume:10 Page:5070-5075
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Zhang Minjie¹,Cui Peng¹,Zhang Kai¹,Shi Zhen¹,Cheng Xu¹,Ji Xiang¹,Song Hao¹,Ke Bowen¹,Qin Yong¹^ORCID

Affiliation:

1. Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan Province, China

Abstract

A general method for Ir-catalyzed asymmetric hydrogenation of tetrasubstituted α-acylpyrazole-β-alkyl cycloalkenes has been developed, furnishing 1,2-cis substituted carbo- or heterocycles with high yields and excellent enantioselectivities.

Funder

Sichuan Province Science and Technology Support Program

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D3QO01196H

Reference40 articles.

1. Reserpine: A Challenge for Total Synthesis of Natural Products

2. The Quest for Quinine: Those Who Won the Battles and Those Who Won the War