Stereochemical investigations of bioactive dihydrobenzofuran-type lignanamides from Solanum lyratum: chiral resolution, in vitro and in silico profiling-Reference-Cited by-同舟云学术

Stereochemical investigations of bioactive dihydrobenzofuran-type lignanamides from Solanum lyratum: chiral resolution, in vitro and in silico profiling

Published:2023 Issue:33 Volume:47 Page:15658-15665
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Chang Ye¹,Duan Zhi-Kang¹,Zhang Xin¹,Hou Jiao-Yang¹,Niu Jia-Qi¹,Yao Guo-Dong¹,Lin Bin²,Song Shao-Jiang¹^ORCID,Bai Ming¹^ORCID,Huang Xiao-Xiao¹^ORCID

Affiliation:

1. Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province, Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China

2. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China

Abstract

Six pairs of enantiomeric dihydrobenzofuran-type lignanamides consisting of nine undescribed compounds (1a, 2a/2b–3a, and 4b–6a/6b), along with a previously undescribed racemic mixture (7), were isolated from Solanum lyratum.

Funder

Liaoning Revitalization Talents Program

Department of Science and Technology of Liaoning Province

Shenyang Pharmaceutical University

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NJ/D3NJ02478D

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2. Anti-angiogenic activities of glycoalkaloids isolated from Solanum lyratum in tumor-derived vascular endothelial cells

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4. Lignans and neolignans with isovaleroyloxy moiety from Solanum lyratum Thunb.: Chiral resolution, configurational assignment and neuroprotective effects

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