Bioinspired human stomach-on-a-chip with <i>in vivo</i> like function and architecture-Reference-Cited by-同舟云学术

Bioinspired human stomach-on-a-chip with in vivo like function and architecture

Published:2023 Issue:3 Volume:23 Page:495-510
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Ferreira Daniel A.¹²³^ORCID,Conde João P.⁴⁵,Rothbauer Mario⁶⁷,Ertl Peter⁸^ORCID,Granja Pedro L.¹²^ORCID,Oliveira Carla¹⁹¹⁰^ORCID

Affiliation:

1. i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal

2. INEB – Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal

3. ICBAS – Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua Jorge de Viterbo Ferreira, 228, 4050-313 Porto, Portugal

4. Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1, 1049-001 Lisboa, Portugal

5. Instituto de Engenharia de Sistemas e Computadores – Microsistemas e Nanotecnologia (INESC MN), Rua Alves Redol, 9, 1000-029 Lisboa, Portugal

6. Department of Orthopedics and Trauma Surgery, Karl Chiari Lab for Orthopaedic Biology, Orthopedic Microsystems, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria

7. Institute of Applied Synthetic Chemistry, Cell Chip Group, Vienna University of Technology (TUW), Getreidmarkt, 9/163, 1060 Vienna, Austria

8. Faculty of Technical Chemistry, Vienna University of Technology (TUW), Getreidemarkt 9, 1060 Vienna, Austria

9. Ipatimup – Institute of Molecular Pathology and Immunology, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal

10. Department of Pathology, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

Abstract

A biomimetic stomach-on-a-chip with integrated peristalsis-like motion and intra-luminal flow. Application of dynamic conditions, elicited differentiation traits that are typical of the normal gastric mucosa, but otherwise lost in 2D culture models.

Funder

Fundação para a Ciência e a Tecnologia

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/LC/D2LC01132H

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