Acidity constant and DFT-based modelling of pH-responsive alendronate loading and releasing on propylamine-modified silica surface-Reference-Cited by-同舟云学术

Acidity constant and DFT-based modelling of pH-responsive alendronate loading and releasing on propylamine-modified silica surface

Published:2021 Issue:3 Volume:23 Page:2015-2024
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Ahmed Khalid¹²³⁴,Inamdar Shaukatali Najikhan¹²³⁴^ORCID,Rohman Nashiour¹²³⁴^ORCID,Skelton Adam A.¹²³⁴^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences

2. University of KwaZulu-Natal

3. Durban 4000

4. South Africa

Abstract

A computational methodology that couples the acidity (K_a) and density functional theory (DFT) calculations has been developed to explain the pH-dependent drug loading on and releasing from mesoporous silica nanoparticles.

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CP/D0CP04498A

Reference64 articles.

1. Influence of pore size of MCM-41 matrices on drug delivery rate

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4. A New Property of MCM-41: Drug Delivery System

5. Synthesis of mesoporous hollow silica nanospheres using polymeric micelles as template and their application as a drug-delivery carrier

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