Synthesis of β-hydroxysulfones through a copper(ii)-catalyzed multicomponent reaction with the insertion of sulfur dioxide-Reference-Cited by-同舟云学术

Synthesis of β-hydroxysulfones through a copper(ii)-catalyzed multicomponent reaction with the insertion of sulfur dioxide

Published:2019 Issue:13 Volume:6 Page:2254-2259
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Zhang Jun¹²³⁴⁵,Xie Wenlin⁶⁷⁸⁴,Ye Shengqing¹²³⁴,Wu Jie¹²³⁴⁵^ORCID

Affiliation:

1. School of Pharmaceutical and Chemical Engineering & Institute for Advanced Studies

2. Taizhou University

3. Taizhou 318000

4. China

5. Department of Chemistry

6. School of Chemistry and Chemical Engineering

7. Hunan University of Science and Technology

8. Xiangtan 411201

Abstract

A copper(ii)-catalyzed aerobic oxidative reaction of arylhydrazines, DABCO·(SO₂)₂ and alkenes is reported. Diverse β-hydroxysulfones are generated in moderate to good yields through the hydroxysulfonylation of alkenes with the insertion of sulfur dioxide under mild conditions. In some cases, β-ketosulfones are produced.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/QO/C9QO00520J

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3. Design, synthesis and biological evaluations of novel pyridone-thiazole hybrid molecules as antitumor agents

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