Design, synthesis, and <i>in vitro</i> and <i>in silico</i> studies of 1,3,4-thiadiazole-thiazolidinone hybrids as carbonic anhydrase inhibitors-Reference-Cited by-同舟云学术

Design, synthesis, and in vitro and in silico studies of 1,3,4-thiadiazole-thiazolidinone hybrids as carbonic anhydrase inhibitors

Published:2023 Issue:29 Volume:47 Page:13710-13720
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Hosseini Nasab Narges¹^ORCID,Raza Hussain¹^ORCID,Eom Young Seok¹,Hassan Mubashir²,Kloczkowski Andrzej²,Chetty Lloyd Christopher³^ORCID,Kruger Hendrik Gert³^ORCID,Kim Song Ja¹^ORCID

Affiliation:

1. Department of Biological Sciences, Kongju National University, Gongju, 32588, Republic of Korea

2. The Steve and Cindy Rasmussen Institute for Genomic Medicine at Nationwide Children's Hospital, Department of Pediatrics, Columbus, Ohio 43205, USA

3. Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa

Abstract

A series of 1,3,4-thiadiazole–thiazolidinones (7a–7j) were synthesized as carbonic anhydrase inhibitors, and based on in vitro analysis the most potent compound was 7i. The kinetic mechanism analysis, MTT assay, and molecular docking studies were also performed.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NJ/D3NJ01547E

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