Molecular insight into chymotrypsin inhibitor 2 resisting proteolytic degradation
Author:
Affiliation:
1. Institute of Theoretical and Computational Chemistry
2. Key Laboratory of Mesoscopic Chemistry
3. School of Chemistry and Chemical Engineering
4. Nanjing University
5. Nanjing 210023
Abstract
Water enters the active site at the EA2 state, so the free energy at EA2 determines the relative hydrolysis rate.
Funder
Natural Science Foundation of Jiangsu Province
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
Physical and Theoretical Chemistry,General Physics and Astronomy
Link
http://pubs.rsc.org/en/content/articlepdf/2019/CP/C8CP07784C
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1. Proteases in cancer drug delivery
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