Fsp3-rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery-Reference-Cited by-同舟云学术

Fsp3-rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery

Published:2020 Issue:15 Volume:56 Page:2280-2283
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Hanby Abigail R.¹²³⁴,Troelsen Nikolaj S.¹²³⁴⁵^ORCID,Osberger Thomas J.¹²³⁴¹,Kidd Sarah L.¹²³⁴⁶,Mortensen Kim T.¹²³⁴^ORCID,Spring David R.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Cambridge

3. Cambridge

4. UK

5. Center for Nanomedicine and Theranostics

6. School of Chemistry

Abstract

Herein, we describe the natural product inspired synthesis of 38 complex small molecules based upon 20 unique frameworks suitable for fragment-based screening.

Funder

Biotechnology and Biological Sciences Research Council

Carlsbergfondet

Royal Society

AstraZeneca

Engineering and Physical Sciences Research Council

Danmarks Tekniske Universitet

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/C9CC09796A

Reference28 articles.

1. The rise of fragment-based drug discovery

2. Twenty years on: the impact of fragments on drug discovery

3. Opportunity Knocks: Organic Chemistry for Fragment-Based Drug Discovery (FBDD)

4. Molecular Complexity and Its Impact on the Probability of Finding Leads for Drug Discovery

5. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

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