Novel latonduine derived proligands and their copper(ii) complexes show cytotoxicity in the nanomolar range in human colon adenocarcinoma cells and in vitro cancer selectivity-Reference-Cited by-同舟云学术

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Novel latonduine derived proligands and their copper(ii) complexes show cytotoxicity in the nanomolar range in human colon adenocarcinoma cells and in vitro cancer selectivity

Published:2019 Issue:28 Volume:48 Page:10464-10478
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Bacher Felix¹²³,Wittmann Christopher¹²³,Nové Márta⁴⁵⁶⁷,Spengler Gabriella⁴⁵⁶⁷^ORCID,Marć Małgorzata A.⁸⁹⁵⁶⁷,Enyedy Eva A.⁸⁹⁵⁶⁷^ORCID,Darvasiová Denisa¹⁰¹¹¹²¹³,Rapta Peter¹⁰¹¹¹²¹³,Reiner Thomas¹⁴¹⁵¹⁶¹⁷¹⁴,Arion Vladimir B.¹²³^ORCID

Affiliation:

1. Institute of Inorganic Chemistry of the University of Vienna

2. A-1090 Vienna

3. Austria

4. Department of Medical Microbiology and Immunobiology

5. University of Szeged

6. H-6720 Szeged

7. Hungary

8. Department of Inorganic and Analytical Chemistry

9. Interdisciplinary Excellence Centre

10. Institute of Physical Chemistry and Chemical Physics

11. Slovak University of Technology in Bratislava

12. 81237 Bratislava

13. Slovak Republic

14. Department of Radiology

15. Weill Cornell Medical College

16. New York City

17. USA

Abstract

The copper(ii) complexes with latonduine derivatives are superior to those with isomeric paullone modified ligands.

Funder

Austrian Science Fund

Emberi Eroforrások Minisztériuma

Nemzeti Kutatási, Fejlesztési és Innovaciós Alap

Vedecká Grantová Agentúra MŠVVaŠ SR a SAV

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/DT/C9DT01238A

Reference39 articles.

1. Basic derivatives of 6,7-dihydroindolo[1,7-ab][1]benzazepine and 6H-indolo[7,1-cd][1,5]benzoxazepine as potential antidepressant agents

2. Conformational and structural features determining in vitro antimalarial activity in some indolo[3,2-c]quinolines, anilinoquinolines and tetrahydroindolo[3,2-d]benzazepines

3. Epoxide-containing side chains enhance antiproliferative activity of paullones

4. Small-Molecule Suppressors of Cytokine-Induced β-Cell Apoptosis

5. 2-Arylpaullones are selective antitrypanosomal agents

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1. Latonduine-1-Amino-Hydantoin Hybrid, Triazole-Fused Latonduine Schiff Bases and Their Metal Complexes: Synthesis, X-ray and Electron Diffraction, Molecular Docking Studies and Antiproliferative Activity;Inorganics;2023-01-03

2. Hydrazylpyridine salicylaldehyde–copper(ii)–1,10-phenanthroline complexes as potential anticancer agents: synthesis, characterization and anticancer evaluation;Dalton Transactions;2023

3. Indolo[2,3-e]benzazocines and indolo[2,3-f]benzazonines and their copper(ii) complexes as microtubule destabilizing agents;Dalton Transactions;2023

4. Elucidation of Structure–Activity Relationships in Indolobenzazepine-Derived Ligands and Their Copper(II) Complexes: the Role of Key Structural Components and Insight into the Mechanism of Action;Inorganic Chemistry;2022-06-17

5. Synthesis of Azepinoindoles via Pd-Catalyzed C(sp²)–H Imidoylative Cyclization Reactions;The Journal of Organic Chemistry;2022-06-13

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