Contributions of supercritical fluid technology for advancing decellularization and postprocessing of viable biological materials

Author:

Duarte Marta M.1ORCID,Silva Inês V.1ORCID,Eisenhut Anthony R.2ORCID,Bionda Nina3,Duarte Ana Rita C.4,Oliveira Ana L.1ORCID

Affiliation:

1. CBQF – Centro de Biotecnologia e Química Fina – Laboratório Associado, Universidade Católica Portuguesa, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal

2. NovaSterilis Inc., 3109 N Triphammer Road, Lansing, NY 14882, USA

3. iFyber, LLC, 950 Danby Road, Ithaca, NY 14850, USA

4. LAQV/REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal

Abstract

This review summarizes relevant literature on scCO2-assisted decellularization, and discusses major topics dominating the field, such as mechanism of action, effect of cosolvent and operational parameters, and range of results across different works.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrical and Electronic Engineering,Process Chemistry and Technology,Mechanics of Materials,General Materials Science

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