Significantly enhanced proteolytic activity of cyclen complexes by monoalkylation-Reference-Cited by-同舟云学术

Significantly enhanced proteolytic activity of cyclen complexes by monoalkylation

Published:2016 Issue:26 Volume:45 Page:10500-10504
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Perera-Bobusch Chrischani¹²³⁴,Hormann Jan¹²³⁴,Weise Christoph¹²³⁴,Wedepohl Stefanie¹²³⁴⁵,Dernedde Jens⁵⁶⁷⁸⁹,Kulak Nora¹²³⁴

Affiliation:

1. Institut für Chemie und Biochemie

2. Freie Universität Berlin

3. 14195 Berlin

4. Germany

5. Charité – Universitätsmedizin Berlin

6. Institut für Laboratoriumsmedizin

7. Klinische Chemie und Pathobiochemie

8. CVK

9. 13353 Berlin

Abstract

The activity of Cu(ii) and Co(iii) cyclen complexes in the cleavage of proteins was remarkably improved by introducing long alkyl chains thus generating efficient proteolytic amphiphilic metal complexes.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/DT/C6DT00681G

Reference46 articles.

1. Metal complexes as artificial proteases in proteomics: A palladium(II) complex cleaves various proteins in solutions containing detergents

2. Molecular and Biotechnological Aspects of Microbial Proteases

3. In the Footsteps of Alchemists

4. Protein folding and misfolding

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