Skipped dienes in natural product synthesis

Author:

Petruncio Greg1ORCID,Shellnutt Zachary1ORCID,Elahi-Mohassel Synah1ORCID,Alishetty Suman2ORCID,Paige Mikell1ORCID

Affiliation:

1. Department of Chemistry & Biochemistry, George Mason University, 10920 George Mason Circle, Manassas, Virginia 20110, USA

2. Department of Bioengineering, George Mason University, 10920 George Mason Circle, Manassas, Virginia 20110, USA

Abstract

The 1,4-diene motif, also known as a skipped diene, is widespread across various classes of natural products including alkaloids, fatty acids, terpenoids, and polyketides as part of either the finalized structure or a biosynthetic intermediate.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference141 articles.

1. Construction of (Z,Z ) skipped 1,4-dienes. Application to the synthesis of polyunsaturated fatty acids and derivatives †

2. Nazarov reaction: current trends and recent advances in the synthesis of natural compounds and their analogs

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4. D.Rogers , Heats of Hydrogenation: Experimental and Computational Hydrogen Thermochemistry of Organic Compounds , World Scientific Publishing Co Pte Ltd , 2006

5. Y.-R.Luo , Handbook of bond dissociation energies in organic compounds , CRC Press , Boca Raton, Fla , 2003

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