Structure–activity relationship of anticancer and antiplasmodial gold bis(dithiolene) complexes

Author:

Vitré Constantin1,Le Gal Yann1,Vacher Antoine1,Roisnel Thierry1ORCID,Lorcy Dominique1ORCID,Santana Sofia2ORCID,Prudêncio Miguel2ORCID,Pinheiro Teresa34ORCID,Marques Fernanda45ORCID

Affiliation:

1. Univ Rennes, CNRS, ISCR (Institut des Sciences Chimiques de Rennes) - UMR 6226, F-35000 Rennes, France

2. iMM-Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal

3. iBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal

4. Departamento de Engenharia e Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Portugal

5. Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Portugal

Abstract

Two series of gold(iii) bis(dithiolene) complex-based therapeutic agents displaying both anticancer and antiplasmodial activities have been synthesized and characterized.

Funder

Université de Rennes 1

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

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