Novel potent HIF-1 inhibitors for the prevention of tumor metastasis: discovery and optimization of 3-aryl-5-indazole-1,2,4-oxadiazole derivatives-Reference-Cited by-同舟云学术

Novel potent HIF-1 inhibitors for the prevention of tumor metastasis: discovery and optimization of 3-aryl-5-indazole-1,2,4-oxadiazole derivatives

Published:2015 Issue:100 Volume:5 Page:81817-81830
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Sheng Rong¹²³⁴⁵,Li Shan¹²³⁴⁵,Lin Guanyu⁶²³⁷⁵,Shangguan Shihao¹²³⁴⁵,Gu Yongchuan⁸⁹¹⁰¹¹,Qiu Ni¹²³⁴⁵,Cao Ji⁶²³⁷⁵,He Qiaojun⁶²³⁷⁵,Yang Bo⁶²³⁷⁵,Hu Yongzhou¹²³⁴⁵

Affiliation:

1. Department of Medicinal Chemistry

2. College of Pharmaceutical Sciences

3. Zhejiang University

4. Hangzhou 310058

5. China

6. Institute of Pharmacology & Toxicology

7. Hangzhou

8. Auckland Cancer Society Research Centre

9. The University of Auckland

10. Auckland

11. New Zealand

Abstract

Our newly synthesized HIF-1 inhibitors 4g and 4h are proved to be the most potential therapeutic agents against tumor metastasis.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA15191K

Reference41 articles.

1. HIF-1 as a target for drug development

2. Hypoxia and Hypoxia-Inducible Factor-1 Expression Enhance Osteolytic Bone Metastases of Breast Cancer

3. Hypoxia-Inducible Factor-1α Is a Key Regulator of Metastasis in a Transgenic Model of Cancer Initiation and Progression

4. Hypoxia in tumors: molecular targets for anti-cancer therapeutics

5. Targeting HIF-1 for cancer therapy

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