HPLC based single-step kinetic assay to screen the activity of DNAzymes-Reference-Cited by-同舟云学术

HPLC based single-step kinetic assay to screen the activity of DNAzymes

Published:2017 Issue:4 Volume:9 Page:697-704
ISSN:1759-9660
Container-title:Analytical Methods
language:en
Short-container-title:Anal. Methods

Author:

Hoefer F.¹²³⁴^ORCID,Marquardt K.¹²³⁴,Schmidts T.¹²³⁴,Domann E.⁵⁶⁷⁸⁴,Runkel F.¹²³⁴

Affiliation:

1. Institute of Bioprocess Engineering and Pharmaceutical Technology

2. University of Applied Sciences Mittelhessen

3. 35390 Giessen

4. Germany

5. Institute for Medical Microbiology

6. German Centre for Infection Research (DZIF Partner Site Giessen-Marburg-Langen)

7. Justus-Liebig University Giessen

8. 35392 Giessen

Abstract

DNAzymes are a new class of biosensors and pharmaceuticals whose mode-of-action is to cleave RNA.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/AY/C6AY03061K

Reference41 articles.

1. Mechanism and Utility of an RNA-Cleaving DNA Enzyme

2. P. I. Pradeepkumar and C.Höbartner, in From nucleic acids sequences to molecular medicine, ed. V. A. Erdmann and J. Barciszewski, Springer, Berlin, London, 2012, pp. 371–410

3. DNA enzymes as potential therapeutics: towards clinical application of 10-23 DNAzymes

4. Safety and tolerability of an intratumorally injected DNAzyme, Dz13, in patients with nodular basal-cell carcinoma: a phase 1 first-in-human trial (DISCOVER)

5. Safety and tolerability of a novel inhaled GATA3 mRNA targeting DNAzyme in patients with TH2-driven asthma

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