Valproic acid causes radiosensitivity of breast cancer cells via disrupting the DNA repair pathway-Reference-Cited by-同舟云学术

Valproic acid causes radiosensitivity of breast cancer cells via disrupting the DNA repair pathway

Published:2016 Issue:3 Volume:5 Page:859-870
ISSN:2045-452X
Container-title:Toxicology Research
language:en
Short-container-title:Toxicol. Res.

Author:

Luo Yue¹²³⁴⁵,Wang Hui¹²³⁴⁵,Zhao Xipeng¹²³⁴⁵,Dong Chao¹²³⁴⁵,Zhang Fengmei¹²³⁴⁵,Guo Gang⁶⁷⁴⁵,Guo Gongshe⁸⁴⁵,Wang Xiaowei⁹¹⁰¹¹¹²,Powell Simon N.¹³¹⁴¹⁵¹²,Feng Zhihui¹²³⁴⁵

Affiliation:

1. Department of Occupational Health and Occupational Medicine

2. The Public Health School

3. Shandong University

4. Shandong

5. China

6. Image Center

7. Jinan Third People's Hospital

8. The Second Hospital of Shandong University

9. Department of Radiation Oncology

10. Washington University School of Medicine

11. St. Louis

12. USA

13. Department of Radiation Oncology and Molecular Biology Program

14. Memorial Sloan Kettering Cancer Center

15. New York

Abstract

Valproic acid (VPA) is one of the representative compounds of histone deacetylase inhibitors (HDACis) and is used widely for the clinical treatment of epilepsy and other convulsive diseases.

Funder

National Natural Science Foundation of China

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://pubs.rsc.org/en/content/articlepdf/2016/TX/C5TX00476D

Reference43 articles.

1. Histone deacetylase inhibitors as radiosensitisers: effects on DNA damage signalling and repair

2. Histone deacetylase inhibitors: Potential in cancer therapy

3. Histone deacetylase inhibitors: A chemical genetics approach to understanding cellular functions