Targeted delivery of LXR-agonists to atherosclerotic lesions mediated by polydiacetylene micelles-Reference-Cited by-同舟云学术

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Targeted delivery of LXR-agonists to atherosclerotic lesions mediated by polydiacetylene micelles

Published:2023 Issue:46 Volume:15 Page:18864-18870
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Jamgotchian Lucie¹,Devel Laurent²^ORCID,Thai Robert²,Poupel Lucie³,Huby Thierry⁴,Gautier Emmanuel⁴,Le Goff Wilfried⁴,Lesnik Philippe⁴,Gravel Edmond¹^ORCID,Doris Eric¹^ORCID

Affiliation:

1. Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SCBM, 91191 Gif-sur-Yvette, France

2. Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SIMOS, 91191 Gif-sur-Yvette, France

3. Inovarion, 251 rue saint Jacques, 75005 Paris, France

4. Sorbonne Université, INSERM UMRS-1166, Institute of Cardiometabolism and Nutrition (ICAN), 75013 Paris, France

Abstract

We report the development of compact and stabilized micelles incorporating a synthetic LXR agonist prodrug for the passive targeting of atherosclerotic lesions and therapeutic intervention.

Funder

Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NR/D3NR04778D

Reference59 articles.

1. Morbidity and mortality associated with atherosclerotic peripheral artery disease: A systematic review

2. Macrophage Accumulation in Atherosclerosis

3. Thrombosis formation on atherosclerotic lesions and plaque rupture

4. Macrophage LXRs inhibit atherosclerosis

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