Novel potential artificial MRSA DNA intercalators: synthesis and biological evaluation of berberine-derived thiazolidinediones
Author:
Affiliation:
1. Institute of Bioorganic & Medicinal Chemistry
2. Key Laboratory of Applied Chemistry of Chongqing Municipality
3. School of Chemistry and Chemical Engineering
4. Southwest University
5. Chongqing 400715
Abstract
Novel berberine-derived thiazolidinediones as potential artificial DNA intercalators were synthesized, and the preliminary mechanism suggested that active compound 6b could intercalate into MRSA DNA.
Funder
National Natural Science Foundation of China
China Postdoctoral Science Foundation
State Administration of Foreign Experts Affairs
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/QO/C8QO01180J
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