A Rh-catalyzed three-component reaction for the diastereoselective synthesis of pyrazolone derivatives with contiguous quaternary stereocenters-Reference-Cited by-同舟云学术

A Rh-catalyzed three-component reaction for the diastereoselective synthesis of pyrazolone derivatives with contiguous quaternary stereocenters

Published:2020 Issue:18 Volume:18 Page:3466-3470
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Ao Chaoqun¹²³⁴⁵,Huang Jingjing¹²³⁴⁵,Xu Xinfang¹²³⁴⁵,Jia Shikun¹²³⁴⁵,Kang Zhenghui¹²³⁴⁵^ORCID,Hu Wenhao¹²³⁴⁵

Affiliation:

1. Guangdong Key Laboratory of Chiral Molecule and Drug Discovery

2. School of Pharmaceutical Sciences

3. Sun Yat-sen University

4. Guangzhou 510006

5. China

Abstract

Efficient approach for the facile construction of polyfunctionalized pyrazolone derivatives bearing two contiguous quaternary stereocenters in good yields with high regioselectivities and excellent diastereoselectivities.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Guangdong Province Introduction of Innovative R&D Team

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB00482K

Reference50 articles.

1. Neuroprotective Effects of Edaravone: a Novel Free Radical Scavenger in Cerebrovascular Injury

2. From 2000 to Mid-2010: A Fruitful Decade for the Synthesis of Pyrazoles

3. Recent Advances in the Chemistry of Pyrazoles. Properties, Biological Activities, and Syntheses

4. Pyrazole containing natural products: Synthetic preview and biological significance

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