A genetically encoded 19F NMR probe for lysine acetylation

Author:

Zhang Feng12345,Zhou Qing56784,Yang Guiwen1234,An Liguo1234,Li Fahui56784ORCID,Wang Jiangyun56784

Affiliation:

1. Shandong Provincial Key Laboratory of Animal Resistance Biology

2. College of Life Science, Shandong Normal University

3. Jinan

4. China

5. Laboratory of RNA Biology

6. Institute of Biophysics

7. Chinese Academy of Sciences

8. Beijing

Abstract

An acetyllysine mimic (TFAcK) has been exploited for detecting the conformational changes of acetylated p53–protein/DNA interactions by genetic code expansion and 19F NMR.

Funder

Chinese Academy of Sciences

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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