Picking the tyrosine-lock: chemical synthesis of the tyrosyl-DNA phosphodiesterase I inhibitor recifin A and analogues-Reference-Cited by-同舟云学术

Picking the tyrosine-lock: chemical synthesis of the tyrosyl-DNA phosphodiesterase I inhibitor recifin A and analogues

Published:2024 Issue:33 Volume:15 Page:13227-13233
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Smallwood Taylor B.¹^ORCID,Krumpe Lauren R. H.²^ORCID,Payne Colton D.¹^ORCID,Klein Victoria G.³^ORCID,O'Keefe Barry R.²⁴^ORCID,Clark Richard J.¹^ORCID,Schroeder Christina I.³⁵^ORCID,Rosengren K. Johan¹^ORCID

Affiliation:

1. The University of Queensland, School of Biomedical Sciences, Brisbane, QLD, 4072, Australia

2. Molecular Targets Program, Centre for Cancer Research, National Cancer Institute, National Institute of Health, Frederick, MD, 21702, USA

3. Chemical Biology Laboratory, Centre for Cancer Research, National Cancer Institute, National Institute of Health, Frederick, MD, 21702, USA

4. Natural Products Branch, Centre for Cancer Research, National Cancer Institute, National Institute of Health, Frederick, MD, 21702, USA

5. Peptide Therapeutics, Genentech Inc, 1 DNA Way, South San Francisco, CA, 94080, USA

Abstract

Chemical synthesis of the peptide recifin A reveals insights into its unique structure and interaction with the cancer target TDP1.

Funder

Center for Cancer Research

Frederick National Laboratory for Cancer Research

U. S. Department of Health and Human Services

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC01976H

Reference24 articles.

1. Statistical Research on the Bioactivity of New Marine Natural Products Discovered during the 28 Years from 1985 to 2012

2. Marine Natural Products in Medicinal Chemistry

3. Recifin A, Initial Example of the Tyr-Lock Peptide Structural Family, Is a Selective Allosteric Inhibitor of Tyrosyl-DNA Phosphodiesterase I

4. Dual DNA topoisomerase 1 and tyrosyl‐DNA phosphodiesterase 1 inhibition for improved anticancer activity

5. Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy