Replacing sulfuric acid with water in electrochemical metal-free mild aromatic C–H amidation: a direct route to <i>N</i>-phenylamides-Reference-Cited by-同舟云学术

Replacing sulfuric acid with water in electrochemical metal-free mild aromatic C–H amidation: a direct route to N-phenylamides

Published:2024 Issue: Volume: Page:
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Kononov Alexander I.¹^ORCID,Strekalova Sofia O.¹^ORCID,Morozov Vladimir I.¹,Boyko Konstantin V.²³,Timashev Vladimir I.²⁴^ORCID,Medvedev Michael G.²⁵^ORCID,Babaeva Olga B.¹,Kobeleva Ekaterina V.¹,Ivshin Kamil A.¹,Babaev Vasily M.¹^ORCID,Budnikova Yulia H.¹^ORCID

Affiliation:

1. Arbuzov Institute of Organic and Physical Chemistry, Kazan, 420088 Russia

2. Zelinsky Institute of Organic Chemistry, Moscow, 119991, Russia

3. Mendeleev University of Chemical Technology of Russia, Moscow, 125047 Russia

4. Lomonosov Moscow State University, Moscow, 119991 Russia

5. National Research University Higher School of Economics, Moscow, 101000 Russia

Abstract

In this work, we describe a mild electro-oxidative metal-, oxidant- and acid-free direct amidation of aromatic C–H bonds using nitrile solvents as a source of amide and amine moieties.

Funder

Russian Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D4QO01296H

Reference61 articles.

1. Amide Bond Bioisosteres: Strategies, Synthesis, and Successes

2. Amide Bond Activation of Biological Molecules

3. Manganese-mediated reductive amidation of esters with nitroarenes

4. Challenges and outlook for catalytic direct amidation reactions

5. Designing Hypothesis of 2-Substituted-N-[4-(1-methyl-4,5-diphenyl-1H-imidazole-2-yl)phenyl] Acetamide Analogs as Anticancer Agents: QSAR Approach