Targeting βCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects-Reference-Cited by-同舟云学术

Targeting βCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects

Published:2017 Issue:9 Volume:9 Page:1260-1270
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Kassa Tigist¹²³⁴⁵,Brad Strader Michael¹²³⁴⁵,Nakagawa Akito⁶⁷⁸⁹¹⁰,Zapol Warren M.⁶⁷⁸⁹¹⁰,Alayash Abdu I.¹²³⁴⁵

Affiliation:

1. Laboratory of Biochemistry and Vascular Biology

2. Center for Biologics Evaluation and Research

3. Food and Drug Administration

4. Silver Spring

5. USA

6. Anesthesia Center for Critical Care Research

7. Department of Anesthesia

8. Critical Care, and Pain Medicine

9. Massachusetts General Hospital and Harvard Medical School

10. Boston

Abstract

Sickle cell disease (SCD) is an inherited blood disorder caused by a β globin gene mutation of hemoglobin (HbS). TD-1 enhances oxygen affinity and prevents sickling of SS RBCs as well as providing protection against iron oxidation.

Funder

National Heart, Lung, and Blood Institute

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MT/C7MT00104E

Reference36 articles.

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4. Autoxidation, dehydration, and adhesivity may be related abnormalities of sickle erythrocytes

5. Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

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