Cu(OAc)<sub>2</sub>-catalyzed three-component cycloaddition of malonates, nitrosoarenes and alkenes: access to isoxazolidines-Reference-Cited by-同舟云学术

Cu(OAc)₂-catalyzed three-component cycloaddition of malonates, nitrosoarenes and alkenes: access to isoxazolidines

Published:2023 Issue:17 Volume:21 Page:3669-3674
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wu Yuting¹,Liu Qiang¹,Huang Shuangping¹,Zhang Chaofeng¹,Wei Wenlong¹,Li Xing¹^ORCID

Affiliation:

1. College of Biomedical Engineering, Taiyuan University of Technology, 79 West Yingze Street, Taiyuan 030024, China

Abstract

The Cu(OAc)2-catalyzed three-component cycloaddition of malonates, nitrosoarenes and alkenes is described. Mechanistic investigations indicated that the formation of nitrone intermediates is the key step.

Funder

Natural Science Foundation of Shanxi Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB00189J

Reference35 articles.

1. Isoxazolidine: A Privileged Scaffold for Organic and Medicinal Chemistry

2. Hughes and Gleason's Virosaine A-Appreciating the Art in Synthesis

3. Stereodivergent Synthesis of Substituted N,O-Containing Bicyclic Compounds by Sequential Addition of Nucleophiles to N-Alkoxybicyclolactams

4. Total Synthesis of Gelsemoxonine through a Spirocyclopropane Isoxazolidine Ring Contraction

5. A Total Synthesis of (±)-Codeine by 1,3-Dipolar Cycloaddition

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