Pyrimidine nucleotides containing a (S)-methanocarba ring as P2Y6 receptor agonists-Reference-Cited by-同舟云学术

Pyrimidine nucleotides containing a (S)-methanocarba ring as P2Y6 receptor agonists

Published:2017 Issue:10 Volume:8 Page:1897-1908
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Toti Kiran S.¹²³⁴⁵,Jain Shanu¹²³⁴⁵,Ciancetta Antonella¹²³⁴⁵^ORCID,Balasubramanian Ramachandran¹²³⁴⁵,Chakraborty Saibal¹²³⁴⁵,Surujdin Ryan¹²³⁴⁵^ORCID,Shi Zhen-Dan⁶⁷⁴⁸⁹,Jacobson Kenneth A.¹²³⁴⁵^ORCID

Affiliation:

1. Molecular Recognition Section

2. Laboratory of Bioorganic Chemistry

3. National Institute of Diabetes and Digestive and Kidney Diseases

4. National Institutes of Health

5. Bethesda

6. Imaging Probe Development Center

7. National Heart, Lung, and Blood Institute

8. Rockville

9. USA

Abstract

Uracil nucleotides containing a south-bicyclo[3.1.0]hexane ((S)-methanocarba) ring system in place of the ribose ring were synthesized and shown to be potent P2Y₆R agonists in a calcium mobilization assay.

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

National Heart, Lung, and Blood Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C7MD00397H

Reference51 articles.

1. International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy

2. Pharmacology and structure of P2Y receptors