A dinuclear ruthenium(ii) phototherapeutic that targets duplex and quadruplex DNA-Reference-Cited by-同舟云学术

A dinuclear ruthenium(ii) phototherapeutic that targets duplex and quadruplex DNA

Published:2019 Issue:12 Volume:10 Page:3502-3513
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Archer Stuart A.¹²³⁴,Raza Ahtasham⁵²⁶⁴,Dröge Fabian¹²³⁴,Robertson Craig¹²³⁴,Auty Alexander J.¹²³⁴,Chekulaev Dimitri¹²³⁴,Weinstein Julia A.¹²³⁴^ORCID,Keane Theo¹²³⁴^ORCID,Meijer Anthony J. H. M.¹²³⁴^ORCID,Haycock John W.⁵²⁶⁴,MacNeil Sheila⁵²⁶⁴,Thomas James A.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Sheffield

3. Sheffield

4. UK

5. Materials Science & Engineering

6. Sheffield S1 3JD

Abstract

A previously reported dinuclear DNA imaging probe has been converted into a phototherapeutic through the incorporation of Ru^II(TAP)₂ fragments (TAP = 1,4,5,8-3 tetraazaphenanthrene).

Funder

Engineering and Physical Sciences Research Council

University of Sheffield

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C8SC05084H

Reference97 articles.

1. Photodynamic therapy (PDT): A short review on cellular mechanisms and cancer research applications for PDT

2. Photodynamic therapy for cancer