The PI3K/AKT/mTOR interactive pathway-Reference-Cited by-同舟云学术

The PI3K/AKT/mTOR interactive pathway

Published:2015 Issue:7 Volume:11 Page:1946-1954
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Ersahin Tulin¹²³⁴⁵,Tuncbag Nurcan¹²³⁴⁵,Cetin-Atalay Rengul¹²³⁴⁵

Affiliation:

1. Cancer Systems Biology Laboratory

2. Graduate School of Informatics

3. ODTU

4. 06800 Ankara

5. Turkey

Abstract

The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of the rapamycin (mTOR) signalling pathway is hyperactivated or altered in many cancer types and regulates a broad range of cellular processes including survival, proliferation, growth, metabolism, angiogenesis and metastasis.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MB/C5MB00101C

Reference125 articles.

1. AKT/PKB Signaling: Navigating Downstream

2. Targeting PI3K signalling in cancer: opportunities, challenges and limitations

3. PI3K and cancer: lessons, challenges and opportunities

4. G Protein–Coupled Receptor–Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness

5. Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

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